This famous quote comes from the 1988 Vice Presidential debate between Dan Quayle and Lloyd Bentsen. Quayle, responding to critics about his experience, drew a comparison between John F. Kennedy's age and his own. Bentsen's response is classic:

"Senator, I served with Jack Kennedy, I knew Jack Kennedy, Jack Kennedy was a friend of mine. Senator, you're no Jack Kennedy."

The video of the Quayle-Bentsen exchange is embedded below: